Basic Information
VIS ID
TVIS44023218
Fusion event
HTLV-1-FLI1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q24.3
Reference genome
GRCh37/hg19
Start
128645456/128775561 (Hg38)
End
128645456/128775561 (Hg38)
Orient
-
Location type
Intronic
Target gene
FLI1
miRNAs that regulate target gene
hsa-mir-145-5p ; hsa-mir-155-5p ; hsa-mir-124-3p
Nearest miRNA
hsa-let-7a-2/Upstream/253112; hsa-mir-4697/Downstream/1891174;
Nearest TSS
ENST00000527297/Upstream/17455; ENST00000528790/Downstream/28315;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/80391, chr11-CpG: 16/Downstream/34876
Nearest cancer related gene
FLI1(OG, No orient, 0)
Upstream sequence
CTGCTTTTTAATTGGTGTCTACCTTGGGGTTCCAGCCTTGGGGACCCTCTAGTGTGAGGTGGTGGCTGGCTGCTAAGCGCCTGCAGGAGGCCATGGGCTG
Downstream sequence
GCGATCGTGTCTGCTCTGTTTCTGCTCTGGATTGCTGGGAACTCCCCCGTGACAACCAGCACTTTAAACGCTTTTAAAGCCTTCAAACACTTTATTGTTT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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