Basic Information
VIS ID
TVIS44023221
Fusion event
HTLV-1-PRDM10 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q24.3
Reference genome
GRCh37/hg19
Start
129788714/129918819 (Hg38)
End
129788714/129918819 (Hg38)
Orient
-
Location type
Intronic
Target gene
PRDM10
miRNAs that regulate target gene
hsa-mir-548c-3p ; hsa-mir-3185 ; hsa-mir-6873-3p ; hsa-mir-6817-3p ; hsa-mir-7110-3p ; hsa-mir-6826-5p ; hsa-mir-513c-3p ; hsa-mir-513a-3p ; hsa-mir-3606-3p ; hsa-mir-4282 ; hsa-mir-6809-3p ; hsa-mir-4776-3p ; hsa-mir-607 ; hsa-mir-4659b-5p ; hsa-mir-4659a-5p ; hsa-mir-5590-5p ; hsa-mir-664b-3p ; hsa-mir-579-3p ; hsa-mir-3671 ; hsa-mir-676-5p ; hsa-mir-1236-3p ; hsa-mir-6515-3p ; hsa-mir-4762-5p ; hsa-mir-7850-5p ; hsa-mir-1305 ; hsa-mir-374b-3p ; hsa-mir-505-3p ; hsa-mir-5191 ; hsa-mir-1250-3p ; hsa-mir-194-3p ; hsa-mir-1182 ; hsa-mir-1178-5p ; hsa-mir-6833-3p ; hsa-mir-4768-5p
Nearest miRNA
hsa-let-7a-2/Upstream/1396370; hsa-mir-4697/Downstream/747916;
Nearest TSS
ENST00000527297/Upstream/23229; ENST00000530583/Downstream/23771;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/23097, chr11-CpG: 119/Downstream/83408
Nearest cancer related gene
PRDM10(OG, No orient, 0)
Upstream sequence
TATTTGGAGAGTATTTTTGAAAACGGGGTAGACACGGGGGTAGAAAATTTTTAACTGAAGGGATCATTTTAAAAATCAATACAAATTAGCAGTCACCACA
Downstream sequence
AGCCTCCAAGAGACATTTGAGTTGCTGGAACACTAGGACGCAGACATGTTAAAAGTGGCTGGGAGTTACTCTGTTCACTAGCAAATATGTGCATTCCAAT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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