Basic Information
VIS ID
TVIS44023231
Fusion event
HTLV-1-GTF2H1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
p15.1
Reference genome
GRCh37/hg19
Start
18364030/18342483 (Hg38)
End
18364030/18342483 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA11C ; FRA11I
Target gene
GTF2H1
miRNAs that regulate target gene
hsa-mir-16-5p ; hsa-mir-15a-5p ; hsa-mir-132-3p ; hsa-mir-1-3p ; hsa-mir-30a-5p ; hsa-mir-100-5p ; hsa-mir-99a-5p ; hsa-mir-574-5p ; hsa-mir-1277-5p ; hsa-mir-493-5p ; hsa-mir-6867-5p ; hsa-mir-190a-3p ; hsa-mir-223-5p ; hsa-mir-511-3p ; hsa-mir-5011-5p ; hsa-mir-5580-3p ; hsa-mir-450b-5p ; hsa-mir-891b ; hsa-mir-466 ; hsa-mir-4789-3p ; hsa-mir-4643 ; hsa-mir-129-5p ; hsa-mir-3680-3p ; hsa-mir-557 ; hsa-mir-507 ; hsa-mir-4325 ; hsa-mir-7703
Nearest miRNA
hsa-mir-210/Upstream/2372862; hsa-let-7a-2/Downstream/45304;
Nearest TSS
ENST00000527297/Upstream/1074; ENST00000528427/Downstream/4621;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/19566, chr11-CpG: 73/Downstream/51892
Upstream sequence
cccaagtagctggaattacaggcacgtgccaccacacccagttaatttttgtatttttagtagagacagggttttgccacgttggccaggctggtctcaa
Downstream sequence
actccttacctcaggtgatctgcccaccttggcctcccaaagtgctgggattacagtcatgagccaccacgcccagccagtgtattttcaatttatactt
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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