Basic Information
VIS ID
TVIS44023250
Fusion event
HTLV-1-ZNF195 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
p15.4
Reference genome
GRCh37/hg19
Start
3396986/3375756 (Hg38)
End
3396986/3375756 (Hg38)
Orient
-
Location type
Intronic
Target gene
ZNF195
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-4264 ; hsa-mir-3149 ; hsa-mir-297 ; hsa-mir-675-3p ; hsa-mir-29b-2-5p ; hsa-mir-4452 ; hsa-mir-1229-3p ; hsa-mir-4753-3p ; hsa-mir-584-5p ; hsa-mir-1257 ; hsa-mir-6862-3p ; hsa-mir-6784-3p ; hsa-mir-6511b-3p ; hsa-mir-6511a-3p ; hsa-mir-199b-5p ; hsa-mir-199a-5p ; hsa-mir-4302 ; hsa-mir-4733-3p ; hsa-mir-1226-3p ; hsa-mir-758-5p ; hsa-mir-218-2-3p ; hsa-mir-5571-5p ; hsa-mir-6870-3p ; hsa-mir-660-3p ; hsa-mir-5193 ; hsa-mir-4793-5p ; hsa-mir-5196-3p ; hsa-mir-622 ; hsa-mir-377-3p ; hsa-mir-6837-3p ; hsa-mir-6754-3p ; hsa-mir-412-3p
Nearest miRNA
hsa-mir-210/Upstream/1202618; hsa-let-7a-2/Downstream/480306;
Nearest TSS
ENST00000527297/Upstream/4609; ENST00000534291/Downstream/3344;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/142510, chr11-CpG: 37/Downstream/3013
Upstream sequence
TAATGGCTACACAGGATGGAATCAATTAGTTTATCAGTTTGAATCTCCAGATCTCATTTTTGTTTTTTACTGAAGTACCAGAAAAACTGGAGTAATTCCC
Downstream sequence
ATGTGGATACCAATGAGGTTTCTTCTCTGAGGGGAGGAACAAACCCTGGGTGACTCATTTCTCTTATTCTACAACAGAAGCACAGATAGACCGTTTTGTC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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