Basic Information
VIS ID
TVIS44023255
Fusion event
HTLV-1-NAT10 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
p13
Reference genome
GRCh37/hg19
Start
34157545/34135998 (Hg38)
End
34157545/34135998 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA11E
Target gene
NAT10
miRNAs that regulate target gene
hsa-mir-375 ; hsa-mir-149-5p ; hsa-mir-4687-3p ; hsa-mir-7974 ; hsa-mir-4718 ; hsa-mir-5580-5p ; hsa-mir-6504-5p ; hsa-mir-3064-5p ; hsa-mir-320e ; hsa-mir-6763-5p ; hsa-mir-3150a-3p ; hsa-mir-6825-5p ; hsa-mir-939-5p ; hsa-mir-1343-5p ; hsa-mir-3175 ; hsa-mir-8089 ; hsa-mir-4700-5p ; hsa-mir-4667-5p ; hsa-mir-759 ; hsa-mir-589-3p ; hsa-mir-5000-5p ; hsa-mir-510-5p ; hsa-mir-512-5p
Nearest miRNA
hsa-mir-210/Upstream/5658450; hsa-let-7a-2/Downstream/805839;
Nearest TSS
ENST00000527297/Upstream/22195; ENST00000530017/Downstream/2874;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/29972, chr11-CpG: 23/Downstream/38444
Upstream sequence
ctgcagtgagctgtgatctcgccactggactctggcctgggtgacagagccagaccctgtctcaagcaatgaaaaaaaaaGTTCAAGCTCAGAGGTTTGT
Downstream sequence
CACTTCCTAAGGCTGTCAGGTGATAGAACCTGGACTTCATGCTGGATCACAGGAGCCTGCCTGTCCCTTTGTAAATCTGTTGGGCAtttttttttttttt
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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