Basic Information
VIS ID
TVIS44023266
Fusion event
HTLV-1-LRRC4C integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
p12
Reference genome
GRCh37/hg19
Start
40719928/40698378 (Hg38)
End
40719928/40698378 (Hg38)
Orient
+
Location type
Intronic
Target gene
LRRC4C
Nearest miRNA
hsa-mir-1343/Upstream/4688174; hsa-let-7a-2/Downstream/2861278;
Nearest TSS
ENST00000527297/Upstream/378648; ENST00000524493/Downstream/696217;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/4187911, chr11-CpG: 49/Downstream/2613511
Upstream sequence
tgaaagttacaaaatgttatctcattaatagaatttacatttcttatattgacactgaggttgaggtttcttcatacgcttattactaacttttaattct
Downstream sequence
tctCTATACTAGCAATCATTGTATTTTGGAGAATAATCCAATTCTGGTCAAGACAGAGTCAATAAGAGCATTTTTTTTTTCCTTTTTTTCTTCCCCTTGT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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