Basic Information
VIS ID
TVIS44023276
Fusion event
HTLV-1-AMBRA1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
p11.2
Reference genome
GRCh37/hg19
Start
46494520/46472970 (Hg38)
End
46494520/46472970 (Hg38)
Orient
-
Location type
Intronic
Target gene
AMBRA1
miRNAs that regulate target gene
hsa-mir-339-5p ; hsa-mir-331-3p ; hsa-mir-186-5p ; hsa-mir-1231 ; hsa-mir-1299 ; hsa-mir-1343-3p ; hsa-mir-208a-3p ; hsa-mir-208b-3p ; hsa-mir-23a-5p ; hsa-mir-23b-5p ; hsa-mir-24-3p ; hsa-mir-3202 ; hsa-mir-3689d ; hsa-mir-3928-5p ; hsa-mir-3929 ; hsa-mir-4419b ; hsa-mir-4478 ; hsa-mir-4533 ; hsa-mir-485-5p ; hsa-mir-555 ; hsa-mir-571 ; hsa-mir-6128 ; hsa-mir-6134 ; hsa-mir-6515-5p ; hsa-mir-6758-5p ; hsa-mir-6776-5p ; hsa-mir-6783-3p ; hsa-mir-6796-3p ; hsa-mir-6806-3p ; hsa-mir-6851-5p ; hsa-mir-6856-5p ; hsa-mir-6861-5p ; hsa-mir-6881-5p ; hsa-mir-6884-5p ; hsa-mir-759 ; hsa-mir-875-3p
Nearest miRNA
hsa-mir-129-2/Upstream/21081; hsa-let-7a-2/Downstream/280155;
Nearest TSS
ENST00000527297/Upstream/54975; ENST00000579280/Downstream/20923;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/79833, chr11-CpG: 45/Downstream/120677
Upstream sequence
TCCAGGAAACACAGGCTTGCTCTTTGGTACCAGTCCCTTACCTCTTGCTCATACCAACTTATAAATCCCACTCTAGAACACAGTGTGACTTCCTCAACCT
Downstream sequence
CAAATCAACCTGATATTACAGTAACAGTTTTAGTAAAGGTATATTTTACACACTGATCAAAACTTATTGGCATACAAGAGTGCTAGATCATGTTAGGAAA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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