Basic Information
VIS ID
TVIS44023281
Fusion event
HTLV-1-TNKS1BP1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q12.1
Reference genome
GRCh37/hg19
Start
57088313/57320839 (Hg38)
End
57088313/57320839 (Hg38)
Orient
-
Location type
Intronic
Target gene
TNKS1BP1
miRNAs that regulate target gene
hsa-mir-130b-3p ; hsa-mir-155-5p ; hsa-mir-1-3p ; hsa-mir-93-5p ; hsa-mir-1296-5p ; hsa-mir-18a-3p ; hsa-mir-484 ; hsa-mir-125b-5p ; hsa-mir-182-5p ; hsa-mir-3157-5p ; hsa-mir-26b-5p ; hsa-mir-3151-5p ; hsa-mir-3202 ; hsa-mir-328-5p ; hsa-mir-4447 ; hsa-mir-4472 ; hsa-mir-4685-5p ; hsa-mir-4723-5p ; hsa-mir-4747-5p ; hsa-mir-491-5p ; hsa-mir-5196-5p ; hsa-mir-520d-5p ; hsa-mir-524-5p ; hsa-mir-5698 ; hsa-mir-6742-5p ; hsa-mir-6795-5p ; hsa-mir-6796-5p ; hsa-mir-6804-5p ; hsa-mir-6837-5p ; hsa-mir-6870-5p ; hsa-mir-6885-5p ; hsa-mir-6887-5p ; hsa-mir-7109-5p ; hsa-mir-7111-5p ; hsa-mir-7113-5p ; hsa-mir-7515 ; hsa-mir-9500
Nearest miRNA
hsa-mir-129-2/Upstream/576858; hsa-let-7a-2/Downstream/320359;
Nearest TSS
ENST00000527297/Upstream/9370; ENST00000534162/Downstream/1358;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/1446195, chr11-CpG: 78/Downstream/3558
Upstream sequence
AGCTGTCAGAAGAACCAGGAAGCAGAACTTCTTTGTTTCCTGTTCCACCTCATCTCCCACCCTCCGATTTAAGAATATTCAcatctttctaggcacaagt
Downstream sequence
catatgccacctcttccatgaagccttccttgattttctaCACACATCCCCAAAGCATCTTCTCCCTTCTTCAAACTCCCAAAATGTTTTAGCCAATTCC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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