Basic Information
VIS ID
TVIS44023288
Fusion event
HTLV-1-FADS3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q12.2
Reference genome
GRCh37/hg19
Start
61650016/61882544 (Hg38)
End
61650016/61882544 (Hg38)
Orient
-
Location type
Intronic
Target gene
FADS3
miRNAs that regulate target gene
hsa-mir-98-5p ; hsa-mir-3127-5p ; hsa-mir-6879-3p ; hsa-mir-6505-3p ; hsa-mir-4778-3p ; hsa-mir-6754-5p ; hsa-mir-4441 ; hsa-mir-4270 ; hsa-mir-211-3p ; hsa-mir-499b-5p ; hsa-mir-4733-3p ; hsa-mir-1226-3p
Nearest miRNA
hsa-mir-129-2/Upstream/4266; hsa-let-7a-2/Downstream/684467;
Nearest TSS
ENST00000527297/Upstream/18; ENST00000533521/Downstream/3787;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/53306, chr11-CpG: 101/Downstream/8553
Upstream sequence
gggcctcactctgtcaccaggctggagtgcagtgatgcaatcacagctcactgcagccttgaaatcctggtcgtaagtgatcctcccacctcagcctccc
Downstream sequence
cagcagctaggactacaggcacatgccaccatgtctcattaacttttgaatttttttgtagagtcaaggtctcactatgttgcctaggcatgtcttaaat
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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