Basic Information
VIS ID
TVIS44023290
Fusion event
HTLV-1-NXF1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q12.3
Reference genome
GRCh37/hg19
Start
62571272/62803800 (Hg38)
End
62571272/62803800 (Hg38)
Orient
-
Location type
Exonic
Target gene
NXF1
miRNAs that regulate target gene
hsa-mir-615-3p ; hsa-mir-487b-3p
Nearest miRNA
hsa-mir-129-2/Upstream/11029; hsa-let-7a-2/Downstream/1538049;
Nearest TSS
ENST00000527297/Upstream/5194; ENST00000535867/Downstream/385;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/11717, chr11-CpG: 68/Downstream/1291
Upstream sequence
TAACAGGTGGGAAAGGAAATGACATGGACAGTAAAAGGGCCATATAATCTCATGAGCCACTAAATTCAAACCAGACCAACTGGTCACTCACTATCGTACT
Downstream sequence
CGGGGACCATCCTGGGCATCACTCATTGCCACATCTCCATCATCTTCCTCAAGGCGGGAAGACCGAATACCAGAACCGCCTCTTCCAGACCTACGGTTTC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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