Basic Information
VIS ID
TVIS44023291
Fusion event
HTLV-1-PLAAT2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q12.3
Reference genome
GRCh37/hg19
Start
63325919/63558447 (Hg38)
End
63325919/63558447 (Hg38)
Orient
+
Location type
Exonic
Fragile sites / regions
FRA11H
Target gene
PLAAT2
Nearest miRNA
hsa-mir-129-2/Upstream/765676; hsa-let-7a-2/Downstream/783402;
Nearest TSS
ENST00000527297/Upstream/20051; ENST00000542805/Downstream/4936;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/67115, chr11-CpG: 73/Downstream/55224
Nearest cancer related gene
PLAAT2(TSG, No orient, 0)
Upstream sequence
GAGTGGCCTGGCTCCTGGGAAGGGGATGCAGGCTGAAGATGCACCTGGTCACTGCGGGAGACGCCATAGCGCAGATGGTTCACGAAGTGCTCGCAGTTGT
Downstream sequence
CACTGGTCAGCGAATAAGGCAACTCCTGCCCCACCAACTCCTCTGCCCGCTTGACGATTTTGTTGGAAGGCAGTGGTGTGTATCTGTCATCGTGCTTGTT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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