Basic Information
VIS ID
TVIS44023310
Fusion event
HTLV-1-RSF1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q14.1
Reference genome
GRCh37/hg19
Start
77504667/77793621 (Hg38)
End
77504667/77793621 (Hg38)
Orient
+
Location type
Intronic
Target gene
RSF1
miRNAs that regulate target gene
hsa-mir-193b-3p ; hsa-mir-155-5p ; hsa-mir-1-3p ; hsa-mir-21-5p ; hsa-mir-218-5p ; hsa-mir-493-5p ; hsa-mir-526b-5p ; hsa-mir-561-5p ; hsa-mir-3171 ; hsa-mir-4635 ; hsa-mir-6830-5p ; hsa-mir-4262 ; hsa-mir-410-3p ; hsa-mir-181d-5p ; hsa-mir-181c-5p ; hsa-mir-181b-5p ; hsa-mir-181a-5p ; hsa-mir-651-3p ; hsa-mir-8485 ; hsa-mir-5582-3p ; hsa-mir-548f-3p ; hsa-mir-548e-3p ; hsa-mir-548az-3p ; hsa-mir-548ar-3p ; hsa-mir-548a-3p ; hsa-mir-4789-5p ; hsa-mir-466 ; hsa-mir-4764-3p ; hsa-mir-6512-5p ; hsa-mir-4643 ; hsa-mir-618 ; hsa-mir-4789-3p ; hsa-mir-4482-3p ; hsa-mir-766-3p ; hsa-mir-138-2-3p ; hsa-mir-4267 ; hsa-mir-508-5p
Nearest miRNA
hsa-mir-10392/Upstream/2458435; hsa-let-7a-2/Downstream/1608401;
Nearest TSS
ENST00000527297/Upstream/28931; ENST00000531855/Downstream/27078;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/155707, chr11-CpG: 16/Downstream/19975
Nearest cancer related gene
RSF1(OG, No orient, 0)
Upstream sequence
tgatgcctagaaaaaacacttcaccagtaaagacacatatagactaaaagaggtggaaagatattccacacagatgaaaaccaaaagtgagcagaagtag
Downstream sequence
ctaaacatatatcagataTggatgtgagggtgatctggctgcgacatctgtcactccactgatcgccaggattgattcagttgatctggctggctaggca
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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