Basic Information
VIS ID
TVIS44023312
Fusion event
HTLV-1-USP35 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q14.1
Reference genome
GRCh37/hg19
Start
77904866/78193820 (Hg38)
End
77904866/78193820 (Hg38)
Orient
-
Location type
Intronic
Target gene
USP35
miRNAs that regulate target gene
hsa-mir-127-3p ; hsa-let-7a-5p
Nearest miRNA
hsa-mir-10392/Upstream/2858634; hsa-let-7a-2/Downstream/1208202;
Nearest TSS
ENST00000527297/Upstream/4913; ENST00000530521/Downstream/2977;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/4876, chr11-CpG: 104/Downstream/2374
Upstream sequence
ATGAGCCACATTCAAAGAGTcaaaaacaacaacaacaacaacaaAACCCAGAATCGAACACATCATTTCCCTCATttcctcattcaggaagcttcgggtg
Downstream sequence
gaccctgaactttttcttttctttttttgagacagggtctcactctatcacttaggctggagtgcagtggcacgatcttgccttacttcacccttgacct
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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