Basic Information
VIS ID
TVIS44023326
Fusion event
HTLV-1-HEPHL1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q21
Reference genome
GRCh37/hg19
Start
93765623/94032457 (Hg38)
End
93765623/94032457 (Hg38)
Orient
-
Location type
Intronic
Target gene
HEPHL1
miRNAs that regulate target gene
hsa-mir-514b-3p ; hsa-mir-514a-3p ; hsa-mir-607 ; hsa-mir-4639-5p ; hsa-mir-489-3p ; hsa-mir-3671 ; hsa-mir-5591-3p ; hsa-mir-506-3p ; hsa-mir-124-3p ; hsa-mir-668-3p ; hsa-mir-1273g-3p ; hsa-mir-3680-5p ; hsa-mir-4262 ; hsa-mir-181d-5p ; hsa-mir-181c-5p ; hsa-mir-181b-5p ; hsa-mir-181a-5p ; hsa-mir-3910 ; hsa-mir-3714 ; hsa-mir-4777-5p ; hsa-mir-526a ; hsa-mir-523-5p ; hsa-mir-522-5p ; hsa-mir-520c-5p ; hsa-mir-519c-5p ; hsa-mir-519b-5p ; hsa-mir-519a-5p ; hsa-mir-518f-5p ; hsa-mir-518e-5p ; hsa-mir-518d-5p ; hsa-mir-8067 ; hsa-mir-6508-5p ; hsa-mir-5010-3p ; hsa-mir-2113 ; hsa-mir-203a-3p ; hsa-mir-223-5p ; hsa-mir-4698 ; hsa-mir-8063
Nearest miRNA
hsa-mir-10392/Upstream/298693; hsa-let-7a-2/Downstream/434038;
Nearest TSS
ENST00000527297/Upstream/11096; ENST00000436171/Downstream/96471;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/181906, chr11-CpG: 19/Downstream/56478
Upstream sequence
TTTATTACGTGGTCTGGGGCAGGCTGGATACCTCAGCTGGCTAGACAGCGGGAGTGATAATCACTTTTTAGCTTGACTTTTAAACCTTGCTGCGCTCTCT
Downstream sequence
TTAAATTATTTTCTTTTTAATTTTGCTATGCTGTAAGCTTCAGTTTACAAATTAGAAAATGTCAAGGTGGCTGTAAACCCCATTTGTTAGCAGGTCCCAA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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