Basic Information
VIS ID
TVIS44023337
Fusion event
HTLV-1-POLR3B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q23.3
Reference genome
GRCh37/hg19
Start
106888071/106494293 (Hg38)
End
106888071/106494293 (Hg38)
Orient
+
Location type
Intronic
Target gene
POLR3B
miRNAs that regulate target gene
hsa-mir-21-5p ; hsa-let-7b-5p
Nearest miRNA
hsa-let-7i/Upstream/1902577; hsa-mir-1178/Downstream/2141517;
Nearest TSS
ENST00000382841/Upstream/84049; ENST00000546882/Downstream/88614;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/136106, chr12-CpG: 41/Downstream/86341
Upstream sequence
AAATGTGTCGATTAAAACTGAAAACACAAAATGTAAGTCATCTCTCTCCTTACCCACCCCCAATATAAGTATGTCATGCTTCCTTGGTCAGTTTCTGCAC
Downstream sequence
CTCCTGCCCCTCTCTCCCACCTTCTCTTGATGGAGGGTGGACAGGCAGCTTCCTCCTGAGCAGACGCCAGCCTCCTCCTGCGAACTGCTGCTTAAGGGGT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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