Basic Information
VIS ID
TVIS44023339
Fusion event
HTLV-1-CRY1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q23.3
Reference genome
GRCh37/hg19
Start
107412626/107018848 (Hg38)
End
107412626/107018848 (Hg38)
Orient
+
Location type
Intronic
Target gene
CRY1
miRNAs that regulate target gene
hsa-mir-324-5p
Nearest miRNA
hsa-let-7i/Upstream/2427132; hsa-mir-1178/Downstream/1616962;
Nearest TSS
ENST00000382841/Upstream/16997; ENST00000547679/Downstream/31511;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/31550, chr12-CpG: 121/Downstream/73986
Upstream sequence
CCTATATTAAGTCAGAGTTTAACTTAGAAAAGAAACTAAGTAAAAAACGCCAGAAAAAATGACAATAGTTTATTAGATATATATGTGTTTACCTAAGTGT
Downstream sequence
GTATAAAAATGTTCTGACCCATTCCTGAATCTACTCCTTATAAACAGAATAAATTGAGTGAATGACACAGAAGAAAGATACATACTAGGGGAGATATCAG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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