Basic Information
VIS ID
TVIS44023342
Fusion event
HTLV-1-ANAPC7 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q24.11
Reference genome
GRCh37/hg19
Start
110815409/110377604 (Hg38)
End
110815409/110377604 (Hg38)
Orient
-
Location type
Exonic
Fragile sites / regions
FRA12E
Target gene
ANAPC7
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-93-3p ; hsa-mir-766-3p ; hsa-mir-484 ; hsa-mir-106b-5p ; hsa-mir-548s ; hsa-mir-3926 ; hsa-mir-3922-3p ; hsa-mir-3176 ; hsa-mir-3190-5p ; hsa-mir-4518 ; hsa-mir-1266-5p ; hsa-mir-3664-3p ; hsa-mir-3155b ; hsa-mir-3155a ; hsa-mir-3126-3p ; hsa-mir-4432 ; hsa-mir-7161-5p ; hsa-mir-548u
Nearest miRNA
hsa-let-7i/Upstream/544168; hsa-mir-1178/Downstream/926538;
Nearest TSS
ENST00000382841/Upstream/31403; ENST00000548449/Downstream/297;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/95347, chr12-CpG: 53/Downstream/25612
Upstream sequence
GGTGGCTAAAAGGGTAAGGGTCTGTGCATTTGCTCCCAGAGTTTTGTAAACGTTGTTAGCCATTACCATTGCTTCTCGAATACTGTTGGAGGCTAAGTAA
Downstream sequence
CATTCGATAAGACCTGAAAAAAGTAAAACACGTGAAGACATTCAATGCCATTACCATTCCAACCCATGCTTCCACTCTGACAGCTCTCCAAATTGCTAAC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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