Basic Information
VIS ID
TVIS44023343
Fusion event
HTLV-1-CUX2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q24.12
Reference genome
GRCh37/hg19
Start
111744964/111307160 (Hg38)
End
111744964/111307160 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA12E
Target gene
CUX2
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-4455 ; hsa-mir-451a ; hsa-mir-552-5p
Nearest miRNA
hsa-let-7i/Upstream/2951; hsa-mir-1178/Downstream/492674;
Nearest TSS
ENST00000382841/Upstream/92859; ENST00000548846/Downstream/56552;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/269722, chr12-CpG: 18/Downstream/3214
Upstream sequence
CCAGATCGCCGACCTGGAGCGGCAGCTCACGGCCAAGTCCGAGGCCATAGAAGTGGGTCCTGGGGAGGAGGCAGGCGGGCAGGCGGCCCCATGCAGAAGC
Downstream sequence
ACACAGACCAGCCTCACCATCTTTCTTTGCTCTTCTAGAAGCTGGAAGAGAAGCTCCAGGCCCAGTCTGACTATGAGGAAATTAAAACGGAGCTGAGGTA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
Curate