Basic Information
VIS ID
TVIS44023345
Fusion event
HTLV-1-ALDH2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q24.12
Reference genome
GRCh37/hg19
Start
112215234/111777430 (Hg38)
End
112215234/111777430 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA12E
Target gene
ALDH2
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-1-3p ; hsa-mir-16-5p ; hsa-mir-615-3p ; hsa-mir-640 ; hsa-mir-4765 ; hsa-mir-6821-3p ; hsa-mir-6790-3p ; hsa-mir-4638-5p ; hsa-mir-8079 ; hsa-mir-1245a
Nearest miRNA
hsa-let-7i/Upstream/473221; hsa-mir-1178/Downstream/22404;
Nearest TSS
ENST00000382841/Upstream/10482; ENST00000549106/Downstream/15181;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/10255, chr12-CpG: 97/Downstream/64458
Upstream sequence
GCTAGTGAATGTTAGCCATGTCCATGACACGCAGAGGGCTGAGTGGACTTCCTCCCTGGGTGGGGGAGGAAGAAGCTTGGGGATAGTACAAGGCCAACCA
Downstream sequence
GACCTACTTCCACCCAGCCCAGCCTAGTGCTTCTCTGTACTCTCCTAACCCTGCTGACCCAAGTGCTTTGCTGTGAGGCAGTTGTGTGTGAGGCGTGAAC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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