Basic Information
VIS ID
TVIS44023347
Fusion event
HTLV-1-RBM19 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q24.21
Reference genome
GRCh37/hg19
Start
114349551/113911746 (Hg38)
End
114349551/113911746 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA12E ; FRA12D
Target gene
RBM19
miRNAs that regulate target gene
hsa-let-7b-5p ; hsa-mir-98-5p ; hsa-mir-26b-5p
Nearest miRNA
hsa-let-7i/Upstream/620138; hsa-mir-1178/Downstream/2236814;
Nearest TSS
ENST00000382841/Upstream/52842; ENST00000550206/Downstream/15685;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/319799, chr12-CpG: 34/Downstream/54451
Upstream sequence
CGTGGTGGCCTGAGGCATCTGATGACCCAGTGGGTGGAATTTGGGCTCTGGAGCTGGTTTCTTCACTGAGAAACAGAGACATGAAACTACTTTACCGGGC
Downstream sequence
CACGGTGATGAATGGGCCCCCAGAAACATGAGGCACTGCAGCGCACGGGGCCGGGGACATGAGAAAGAAATCAACACTCACACGTATTACCACAGCATCA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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