Basic Information
VIS ID
TVIS44023353
Fusion event
HTLV-1-PEBP1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q24.23
Reference genome
GRCh37/hg19
Start
118574412/118136607 (Hg38)
End
118574412/118136607 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA12E ; FRA12C
Target gene
PEBP1
miRNAs that regulate target gene
hsa-mir-224-5p ; hsa-mir-375 ; hsa-mir-155-5p ; hsa-mir-222-3p ; hsa-mir-92a-3p ; hsa-mir-181a-5p ; hsa-mir-181b-5p ; hsa-mir-181c-5p ; hsa-mir-181d-5p ; hsa-mir-340-5p ; hsa-mir-759 ; hsa-mir-3174 ; hsa-mir-5586-3p ; hsa-mir-539-5p ; hsa-mir-4753-5p ; hsa-mir-4755-3p ; hsa-mir-6768-3p ; hsa-mir-4765 ; hsa-mir-1236-5p ; hsa-mir-5590-3p ; hsa-mir-142-5p ; hsa-mir-551b-5p ; hsa-mir-4484 ; hsa-mir-548an ; hsa-mir-4282 ; hsa-mir-4685-3p ; hsa-mir-4287 ; hsa-mir-6875-3p ; hsa-mir-103a-2-5p ; hsa-mir-4778-3p ; hsa-mir-1976 ; hsa-mir-4469 ; hsa-mir-6893-3p ; hsa-mir-370-3p ; hsa-mir-660-3p ; hsa-mir-4667-3p ; hsa-mir-1470 ; hsa-mir-665 ; hsa-mir-27a-5p
Nearest miRNA
hsa-let-7i/Upstream/1708289; hsa-mir-1178/Downstream/1577027;
Nearest TSS
ENST00000382841/Upstream/581; ENST00000542939/Downstream/2410;
Nearest CpG islands
chr12-CpG: 89/Target, None/Upstream, None/Downstream
Nearest cancer related gene
PEBP1(TSG, No orient, 0)
Upstream sequence
TGGGGGCCACCCCGAGCACCGGGAACCCGGCCTGTGGCGTGGCCAGGCAGGTTCGGCCTGCGGCAGAAATTCATTCACTTTTCCCGGGCTTCAGACCCAA
Downstream sequence
GAGGGACCTAGGTTCGGAAACAGGCCGGATCCCCCTCTCCCCCCACAGGCCAGGGCGCTGGAGAGGGACGTCGCCGGGACAGAGTAGGCTGTGGCTGCCC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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