Basic Information
VIS ID
TVIS44023357
Fusion event
HTLV-1-BCL2L14 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
p13.2
Reference genome
GRCh37/hg19
Start
12245659/12092725 (Hg38)
End
12245659/12092725 (Hg38)
Orient
+
Location type
Intronic
Target gene
BCL2L14
miRNAs that regulate target gene
hsa-mir-7107-3p ; hsa-mir-6753-3p ; hsa-mir-6503-5p ; hsa-mir-4527 ; hsa-mir-8069 ; hsa-mir-570-3p ; hsa-mir-4635 ; hsa-mir-4679 ; hsa-mir-4677-3p ; hsa-mir-3663-5p
Nearest miRNA
hsa-mir-1244-3/Upstream/2853174; hsa-let-7i/Downstream/19227;
Nearest TSS
ENST00000382841/Upstream/13426; ENST00000543990/Downstream/39105;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/443106, chr12-CpG: 102/Downstream/174020
Upstream sequence
TTTGATTCTTTTACTGTTCTGGCACAGTCCCCACTTGGCTGCCTGCTAGGGTTTTGAGCCTGGCCTCCTCCATTGGGAAACTGATGAAGAGGAGTCTGTT
Downstream sequence
CCCTGTTATGGAGGAGGCTGGCCATGCCTCCTGCAGAGTCACAACCCAGACGGGGCCTGGACGGTGGGGGTGGGCGTGGTTCAGGGAAAAGACAGGTCTG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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