Basic Information
VIS ID
TVIS44023365
Fusion event
HTLV-1-RIMBP2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q24.33
Reference genome
GRCh37/hg19
Start
130979399/130494854 (Hg38)
End
130979399/130494854 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA12E
Target gene
RIMBP2
miRNAs that regulate target gene
hsa-mir-514b-5p ; hsa-mir-513c-5p ; hsa-mir-372-5p ; hsa-mir-371a-5p ; hsa-mir-616-5p ; hsa-mir-373-5p ; hsa-mir-371b-5p ; hsa-mir-4286 ; hsa-mir-330-3p
Nearest miRNA
hsa-let-7i/Upstream/2200676; hsa-mir-6763/Downstream/2087143;
Nearest TSS
ENST00000382841/Upstream/15838; ENST00000443685/Downstream/11916;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/25570, chr12-CpG: 20/Downstream/146449
Upstream sequence
CTTCCCTGCTGTCCAGAGCACTTGGCCTTATGTGGGAAAAGGATGCATTTGTGACCGCTGGGTCacaaagtaccacaactggcacttctgcttaagacaa
Downstream sequence
tggaaagtgtcctctcacagccctggagcacagaaggctgaaatccaggtgtcggcagggccggatcctctcgtggaacctctgagggagaagccgcccc
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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