Basic Information
VIS ID
TVIS44023379
Fusion event
HTLV-1-RASSF8 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
p12.1
Reference genome
GRCh37/hg19
Start
26167098/26014165 (Hg38)
End
26167098/26014165 (Hg38)
Orient
-
Location type
Intronic
Target gene
RASSF8
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-375 ; hsa-mir-130b-3p ; hsa-mir-9-5p ; hsa-mir-148a-3p ; hsa-mir-192-5p ; hsa-mir-629-5p ; hsa-mir-19a-5p ; hsa-mir-19b-1-5p ; hsa-mir-19b-2-5p ; hsa-mir-219a-5p ; hsa-mir-200b-3p ; hsa-mir-200c-3p ; hsa-mir-429 ; hsa-mir-511-5p ; hsa-mir-508-3p ; hsa-mir-1245a ; hsa-mir-2052 ; hsa-mir-3121-3p ; hsa-mir-4427 ; hsa-mir-4445-5p ; hsa-mir-4724-5p ; hsa-mir-4782-3p ; hsa-mir-6766-3p ; hsa-mir-8062 ; hsa-mir-8079 ; hsa-mir-6830-3p ; hsa-mir-224-5p
Nearest miRNA
hsa-mir-1244-3/Upstream/140086; hsa-let-7i/Downstream/16309535;
Nearest TSS
ENST00000382841/Upstream/2387; ENST00000537946/Downstream/7275;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/54775, chr12-CpG: 59/Downstream/99960
Nearest cancer related gene
RASSF8(TSG, No orient, 0)
Upstream sequence
GTGCCCTGCCTGAGCTGCCAGTGCCTTTGTACAGCAGGTATAGGCACAGCCAGCTGGTGCCTTGTGCCCGGTGACTTGCCAAGTGGGTGCTCACTCACTA
Downstream sequence
CAGCAGCAAACTTCAGCAAATGTGTTTTAACTAATAACGTTCATACTAGCGATGAAAACATATGTATGTGTTtcctatgcccatggcagacataattagt
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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