Basic Information
VIS ID
TVIS44023423
Fusion event
HTLV-1-LGR5 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
71863367/71469587 (Hg38)
End
71863367/71469587 (Hg38)
Orient
+
Location type
Intronic
Target gene
LGR5
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-142-3p ; hsa-mir-3679-3p ; hsa-mir-526b-5p ; hsa-mir-361-3p ; hsa-mir-6793-3p
Nearest miRNA
hsa-let-7i/Upstream/1884764; hsa-mir-1178/Downstream/7949670;
Nearest TSS
ENST00000382841/Upstream/27689; ENST00000549015/Downstream/97675;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/28978, chr12-CpG: 83/Downstream/193401
Upstream sequence
CGGTTCAGGAGCAGCACGCTCTGGCCTTGTTTGCCCATTTCCCTGGGCCGCTGACAGTGATCTGACAGAAAGCGACACTGACACAAAGAAGCCAAGAGGG
Downstream sequence
GCAGGAGATGGGGGTGAGGTCAAAGCGGAGAAACTGAGAAAATCCAGTGAAGTGGAAGCTGAAAGGATAAACGCATGAAGGCTTAGAGCCGCTTCTCGGC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
Curate