Basic Information
VIS ID
TVIS44023427
Fusion event
HTLV-1-ACSS3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q21.31
Reference genome
GRCh37/hg19
Start
81505076/81111297 (Hg38)
End
81505076/81111297 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA12B
Target gene
ACSS3
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-3680-3p ; hsa-mir-557 ; hsa-mir-507 ; hsa-mir-450b-5p ; hsa-mir-664b-3p ; hsa-mir-579-3p ; hsa-mir-4480 ; hsa-mir-153-5p ; hsa-mir-1250-3p ; hsa-mir-7849-3p ; hsa-mir-23c ; hsa-mir-23a-3p ; hsa-mir-23b-3p ; hsa-mir-130a-5p
Nearest miRNA
hsa-let-7i/Upstream/175464; hsa-mir-1178/Downstream/47091;
Nearest TSS
ENST00000382841/Upstream/33240; ENST00000548387/Downstream/14548;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/32957, chr12-CpG: 34/Downstream/647244
Upstream sequence
AAGAGCAGAAGTGAGGAGTTAAGAAGAACCCACAAATTGTCCAATAACTAGACTCACTGCCTTGAGTCAATCTTCTAGATTGAAAGACAGAGTAGTAACA
Downstream sequence
TCtgtcatgctgaacccctattgactccagtggggatggcaccaggttcaagaggccaaagaagagacccagagccccatacaagacatggggttttact
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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