Basic Information
VIS ID
TVIS44023441
Fusion event
HTLV-1-KERA integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q21.33
Reference genome
GRCh37/hg19
Start
91445270/91051493 (Hg38)
End
91445270/91051493 (Hg38)
Orient
-
Location type
Exonic
Fragile sites / regions
FRA12B
Target gene
KERA
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-let-7i/Upstream/4306344; hsa-mir-1178/Downstream/3510296;
Nearest TSS
ENST00000382841/Upstream/46467; ENST00000551571/Downstream/6490;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/97174, chr12-CpG: 128/Downstream/1093441
Upstream sequence
TGGAATTGGTGGTTTGATTTCATTTCCATCCAGACGGAGGTAGCGAAGATGAGGTCCATAACTGAAGGAATCTCGTTCTGCAGGCAGCATGGATGGGCTG
Downstream sequence
GGACATATTACAGAGACATTCACACCTACAGTGACAAAGAGAATAGATGAATGAATTGGAACACAAGAGAAACTAACAGTGGGAAGACCAAAAAACTAAT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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