Basic Information
VIS ID
TVIS44023443
Fusion event
HTLV-1-VEZT integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q22
Reference genome
GRCh37/hg19
Start
95691421/95297645 (Hg38)
End
95691421/95297645 (Hg38)
Orient
+
Location type
Intronic
Target gene
VEZT
miRNAs that regulate target gene
hsa-mir-30a-3p ; hsa-mir-375 ; hsa-mir-103a-3p ; hsa-mir-101-3p ; hsa-mir-16-5p ; hsa-mir-34c-5p ; hsa-mir-2276-3p ; hsa-mir-6836-3p ; hsa-mir-5001-3p ; hsa-mir-891a-3p ; hsa-mir-4284 ; hsa-mir-564 ; hsa-mir-3194-3p ; hsa-mir-6791-3p ; hsa-mir-6829-3p ; hsa-mir-6778-3p ; hsa-mir-4638-5p ; hsa-mir-1307-3p ; hsa-mir-1304-3p ; hsa-mir-6741-3p ; hsa-mir-5693 ; hsa-mir-6890-3p ; hsa-mir-6796-3p ; hsa-mir-5698 ; hsa-mir-143-5p ; hsa-mir-504-3p ; hsa-mir-6499-3p ; hsa-mir-4279 ; hsa-mir-4423-3p ; hsa-mir-365b-5p ; hsa-mir-365a-5p ; hsa-mir-8052 ; hsa-mir-3199 ; hsa-mir-1976 ; hsa-mir-3653-5p ; hsa-mir-6747-3p ; hsa-mir-6727-3p ; hsa-mir-4722-3p ; hsa-mir-4740-3p ; hsa-mir-1295b-3p ; hsa-mir-3622a-5p ; hsa-mir-5582-5p ; hsa-mir-625-3p
Nearest miRNA
hsa-let-7i/Upstream/463132; hsa-mir-1178/Downstream/10775;
Nearest TSS
ENST00000382841/Upstream/1576; ENST00000549136/Downstream/90913;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/79424, chr12-CpG: 39/Downstream/176163
Nearest cancer related gene
VEZT(TSG, No orient, 0)
Upstream sequence
TGACTTCCATTTTCAGTACTTTTTTCTTCTAAGCTATCTTGCAAACTCTTTGCAGATTTTTCTCCAACACTGCATTGATGATGGCTCTCTATCTTAAAAC
Downstream sequence
CTATAGTGGTTTCTCCCTTTCTTATTGTGTTGAATCTAAACTCTTTTTCCTGTTTTCAAGTCTCTTCATCATAAGAATTCATCTATCCAATTATATTTTC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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