Basic Information
VIS ID
TVIS44023457
Fusion event
HTLV-1-MYO16 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr13
Cytoband
q33.3
Reference genome
GRCh37/hg19
Start
109543490/108891142 (Hg38)
End
109543490/108891142 (Hg38)
Orient
-
Location type
Intronic
Target gene
MYO16
miRNAs that regulate target gene
hsa-mir-4695-3p ; hsa-mir-602 ; hsa-mir-8485 ; hsa-mir-548b-3p ; hsa-mir-3133
Nearest miRNA
hsa-mir-1267/Upstream/1359894; hsa-mir-4502/Downstream/1449816;
Nearest TSS
ENST00000623511/Upstream/35846; ENST00000618966/Downstream/210777;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/394471, chr13-CpG: 22/Downstream/236193
Upstream sequence
AGCTCAGTTTCTATGTGGGGAATAAATGAATATACTAAAATAAGTATCGTGACCGTATAGGAGAAACATTTCATTACCCCCAGTTTCCTAAGTTAAGTTC
Downstream sequence
CTTAGTTAACTTTACATTATCAAATACATTTAATGTGGACAACCCATTTGTATGTCATCAGGAGGCTGTACATTTGGCCTGTGTGTGTTTCCTTATATGT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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