Basic Information
VIS ID
TVIS44023459
Fusion event
HTLV-1-ARHGEF7 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr13
Cytoband
q34
Reference genome
GRCh37/hg19
Start
111951633/111299286 (Hg38)
End
111951633/111299286 (Hg38)
Orient
-
Location type
Intronic
Target gene
ARHGEF7
miRNAs that regulate target gene
hsa-mir-24-3p ; hsa-mir-18a-3p ; hsa-mir-20a-5p ; hsa-mir-17-5p ; hsa-mir-580-5p ; hsa-mir-3919 ; hsa-mir-5680 ; hsa-mir-541-5p ; hsa-mir-106b-5p ; hsa-mir-4642 ; hsa-mir-1256 ; hsa-mir-509-3p ; hsa-mir-3185 ; hsa-mir-519d-3p ; hsa-mir-93-5p ; hsa-mir-20b-5p
Nearest miRNA
hsa-mir-1267/Upstream/958257; hsa-mir-4502/Downstream/1963634;
Nearest TSS
ENST00000623511/Upstream/16458; ENST00000283547/Downstream/16898;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/15951, chr13-CpG: 36/Downstream/26955
Upstream sequence
TGGTTCCTGTTGCACGCTGCTGTGGAAATAACAGTGGTGCCCTCGCGTGTCAGGAACGTCTTATGAGACATCTTAAGCTTTGGCATCATCCTTAACCTTG
Downstream sequence
TTCTGCTCAGGGGAGCCTAAGCGTGCAGTAAAATGCTGGTGAAGCCATTCAtttttttttttttttttttttttgagacggagtctcgctctgtcgccca
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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