Basic Information
VIS ID
TVIS44023462
Fusion event
HTLV-1-TMCO3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr13
Cytoband
q34
Reference genome
GRCh37/hg19
Start
114185771/113531456 (Hg38)
End
114185771/113531456 (Hg38)
Orient
+
Location type
Intronic
Target gene
TMCO3
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-30c-5p
Nearest miRNA
hsa-mir-1267/Upstream/268457; hsa-mir-4502/Downstream/713049;
Nearest TSS
ENST00000623511/Upstream/10910; ENST00000491166/Downstream/14299;
Nearest CpG islands
chr13-CpG: 34/Target, None/Upstream, None/Downstream
Upstream sequence
GGAAGCTTGTCCAAACACGCTGAGACAGTCAGAACAGCCGTGGACACGGCGCCCCGTATGTGCAGATCAAGAGCAGCACACGCGTGGACCTGCAGGTGGC
Downstream sequence
ACGGCGCCCTGTACATACAGATCAAGAGCAGCATGCGTGTGGACCTGCAGGTGACACGGCGCCCCGTACGTGCAGATCAAGAGCAGCACACGCGTGGACC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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