Basic Information
VIS ID
TVIS44023463
Fusion event
HTLV-1-ZMYM2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr13
Cytoband
q12.11
Reference genome
GRCh37/hg19
Start
20635710/20061570 (Hg38)
End
20635710/20061570 (Hg38)
Orient
+
Location type
Intronic
Target gene
ZMYM2
miRNAs that regulate target gene
hsa-mir-21-5p ; hsa-mir-19b-3p ; hsa-mir-1229-3p ; hsa-mir-23b-3p ; hsa-let-7b-5p ; hsa-mir-103a-2-5p ; hsa-mir-4772-5p ; hsa-mir-383-5p ; hsa-mir-2681-5p ; hsa-mir-1305 ; hsa-mir-524-5p ; hsa-mir-520d-5p ; hsa-mir-431-5p ; hsa-mir-5093 ; hsa-mir-3682-3p ; hsa-mir-153-5p ; hsa-mir-651-3p ; hsa-mir-203a-3p ; hsa-mir-1277-5p ; hsa-mir-6083 ; hsa-mir-5696 ; hsa-mir-190a-3p ; hsa-mir-4789-5p ; hsa-mir-3941 ; hsa-mir-4729 ; hsa-mir-5011-5p ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485 ; hsa-mir-5580-3p ; hsa-mir-4789-3p
Nearest miRNA
hsa-mir-1267/Downstream/372208;
Nearest TSS
ENST00000623511/Upstream/35051; ENST00000490152/Downstream/5008;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/102080, chr13-CpG: 24/Downstream/56815
Nearest cancer related gene
ZMYM2(OG, No orient, 0)
Upstream sequence
CAACTCAAAATTATTCTTGTTAATGGAGTAGTGCTGATGCAAAACTATAATAACTTGTAGTAGACTCTAATGATGATCAAAACTCTTATTTTGTAATAGT
Downstream sequence
TATCCCTAGTTttttgttttgttttgtttttttttttagatgaactcttgctctgttgcccagggtggagtgtagtagcatgatcccggttcactgagat
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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