Basic Information
VIS ID
TVIS44023486
Fusion event
HTLV-1-PDS5B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr13
Cytoband
q13.1
Reference genome
GRCh37/hg19
Start
33271745/32697608 (Hg38)
End
33271745/32697608 (Hg38)
Orient
+
Location type
Intronic
Target gene
PDS5B
miRNAs that regulate target gene
hsa-mir-27a-3p ; hsa-mir-92a-3p
Nearest miRNA
hsa-mir-2276/Upstream/8535104; hsa-mir-1267/Downstream/6966426;
Nearest TSS
ENST00000623511/Upstream/111039; ENST00000481616/Downstream/3376;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/109910, chr13-CpG: 157/Downstream/318182
Nearest cancer related gene
PDS5B(TSG, No orient, 0)
Upstream sequence
TTCCAAGATGTGTATGAAAGTAATGTTAAGACACTGAAGATAACAGTAAACCTAACTCACTGGTTTTTGGATTAAGTAATGGGAATATTAGAATGAGTAG
Downstream sequence
AACTTTAAGACCAAAATGTTCTTCTGTCCTGGGAAAACTACTTTCCAGTCCCCTGGGTAACTTGCTAAAGCAAGTTGTTTTGTGCTAGTCCTTTTACAAA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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