Basic Information
VIS ID
TVIS44023491
Fusion event
HTLV-1-NBEA integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr13
Cytoband
q13.3
Reference genome
GRCh37/hg19
Start
35576174/35002037 (Hg38)
End
35576174/35002037 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA13A
Target gene
NBEA
miRNAs that regulate target gene
hsa-mir-548b-3p ; hsa-mir-335-5p ; hsa-mir-9-5p ; hsa-mir-128-3p ; hsa-mir-21-5p ; hsa-mir-935 ; hsa-mir-18a-5p ; hsa-mir-377-3p ; hsa-mir-485-3p ; hsa-mir-127-3p ; hsa-mir-409-5p
Nearest miRNA
hsa-mir-2276/Upstream/10839533; hsa-mir-1267/Downstream/4661997;
Nearest TSS
ENST00000623511/Upstream/59377; ENST00000497540/Downstream/67915;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/58747, chr13-CpG: 54/Downstream/468670
Upstream sequence
tgttaattaaaaattaaaATAGGTGACAGTATATCCCCGTATCACTGAATATGAGTAAAACAATGGATAGCAGCAAGAATTATGGGGGAATAGCCAGTGA
Downstream sequence
CCAGGAATGGTTAAAGGAAAGATAAACTATGGTGTATTCTAAGATCTGAGGAAACCAGAAACCACAAGCAAGTGTTCACCTCCAAAAAAGGTACCCTCAG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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