Basic Information
VIS ID
TVIS44023499
Fusion event
HTLV-1-ENOX1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr13
Cytoband
q14.11
Reference genome
GRCh37/hg19
Start
44264389/43690253 (Hg38)
End
44264389/43690253 (Hg38)
Orient
-
Location type
Intronic
Target gene
ENOX1
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-599 ; hsa-mir-3161 ; hsa-mir-526b-5p ; hsa-mir-5692c ; hsa-mir-5692b ; hsa-mir-5692a ; hsa-mir-2681-5p
Nearest miRNA
hsa-mir-2276/Upstream/2121858; hsa-mir-1267/Downstream/505876;
Nearest TSS
ENST00000623511/Upstream/146335; ENST00000604480/Downstream/96655;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/666533, chr13-CpG: 159/Downstream/95645
Upstream sequence
CTTTAGAATGTAAGGTATTCAGGACAACCATGGGAGTTCTGAGATTTTTGTATTTAGAACACTCTTTTTAGCAAAAGAACATCCAGCCTTGCttataaat
Downstream sequence
aagttaaaaaaaaaaaaaaaaaGACAAGCAGATTAAAAAAAGCTGCCCAGGAGGCACTCATAGAAAAAACAAAATTAGTAACCTCTTCTACTTGCCCAGC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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