Basic Information
VIS ID
TVIS44023501
Fusion event
HTLV-1-COG3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr13
Cytoband
q14.13
Reference genome
GRCh37/hg19
Start
46091591/45517456 (Hg38)
End
46091591/45517456 (Hg38)
Orient
-
Location type
Intronic
Target gene
COG3
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-32-5p ; hsa-mir-92a-3p ; hsa-mir-92b-3p
Nearest miRNA
hsa-mir-2276/Upstream/1321256; hsa-mir-1267/Downstream/4478959;
Nearest TSS
ENST00000623511/Upstream/1309; ENST00000533564/Downstream/32812;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/51910, chr13-CpG: 63/Downstream/195691
Upstream sequence
GAGAGCCAGTGTAACCTCATGATGATTCTTCTTAAAACAGTTTGCTCTATTTCGTTCCCTAGTGCTCTCTCTTGTCCACCACGGAGAATATGTTTTGGTT
Downstream sequence
CTGTAAAGCATGTGTGTTATGTACTTTGTGattttaaaatttttaaattatttttgtttttttCTCTAATCTTGGAAGTGGCACACCATGTGTTTTTGTT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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