Basic Information
VIS ID
TVIS44023581
Fusion event
HTLV-1-RAB2B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
21945002/21476843 (Hg38)
End
21945002/21476843 (Hg38)
Orient
+
Location type
Exonic
Target gene
RAB2B
miRNAs that regulate target gene
hsa-mir-421 ; hsa-mir-765 ; hsa-mir-6779-5p ; hsa-mir-6780a-5p ; hsa-mir-3689c ; hsa-mir-3689b-3p ; hsa-mir-3689a-3p ; hsa-mir-30b-3p ; hsa-mir-1273h-5p ; hsa-mir-6778-5p ; hsa-mir-1233-5p ; hsa-mir-3175 ; hsa-mir-6799-5p ; hsa-mir-6883-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-7106-5p ; hsa-mir-6878-5p ; hsa-mir-6739-5p ; hsa-mir-6733-5p ; hsa-mir-3153 ; hsa-mir-5703 ; hsa-mir-4516 ; hsa-mir-6077 ; hsa-mir-4434 ; hsa-mir-6770-5p ; hsa-mir-7153-5p ; hsa-mir-146b-5p ; hsa-mir-146a-5p ; hsa-mir-1252-5p ; hsa-mir-6730-5p ; hsa-mir-7113-5p ; hsa-mir-5584-5p ; hsa-mir-3925-5p ; hsa-mir-6805-3p ; hsa-mir-5691 ; hsa-mir-3194-3p ; hsa-mir-4662a-3p ; hsa-mir-548an ; hsa-mir-19b-3p ; hsa-mir-181d-5p ; hsa-mir-19a-3p ; hsa-mir-181c-5p ; hsa-mir-181b-5p ; hsa-mir-181a-5p
Nearest miRNA
hsa-mir-6717/Upstream/453457; hsa-mir-1185-1/Downstream/1480107;
Nearest TSS
ENST00000550708/Upstream/88; ENST00000487242/Downstream/93;
Nearest CpG islands
chr14-CpG: 60/Target, None/Upstream, None/Downstream
Upstream sequence
CAAAGTGAGCCCCGCCCCCGCCACCCAATTTGGGAGCTTCGAATGCCCGCCCGAGCCTTGAAGGCGAACCACCTGAGGGTTACCTGTGTCTCCGATGATG
Downstream sequence
ATATACTTGAAGAGATAAGCATAAGTCATGGTGTCGCGTCCTCTGGGTTCCGGGTCCGCCCGACTTCTATAGCCACTTACCTCCGACCTCTCTAGCCACT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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