Basic Information
VIS ID
TVIS44023599
Fusion event
HTLV-1-AKAP6 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q12
Reference genome
GRCh37/hg19
Start
32943367/32474161 (Hg38)
End
32943367/32474161 (Hg38)
Orient
-
Location type
Intronic
Target gene
AKAP6
miRNAs that regulate target gene
hsa-mir-1257 ; hsa-mir-4687-3p ; hsa-mir-7974 ; hsa-mir-583 ; hsa-mir-1276 ; hsa-mir-4311 ; hsa-mir-1303 ; hsa-mir-5096 ; hsa-mir-3187-3p ; hsa-mir-4435 ; hsa-mir-588 ; hsa-mir-4701-5p ; hsa-mir-548s ; hsa-mir-7641 ; hsa-mir-197-3p ; hsa-mir-411-5p ; hsa-mir-6832-5p ; hsa-mir-193b-5p ; hsa-mir-4755-3p ; hsa-mir-4695-3p ; hsa-mir-4716-5p ; hsa-mir-4781-3p ; hsa-mir-4478 ; hsa-mir-4419b ; hsa-mir-3929 ; hsa-mir-483-5p
Nearest miRNA
hsa-mir-208a/Upstream/1459419; hsa-mir-1185-1/Downstream/4478148;
Nearest TSS
ENST00000550708/Upstream/404; ENST00000554410/Downstream/20110;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/270452, chr14-CpG: 168/Downstream/458727
Upstream sequence
taatttttgtatttttggtagaaacggggtttcactatgttggccaggctggtctcaaactcctgatctcaggtgatccacccgcctcggcctcccaaag
Downstream sequence
tgctgggattacaggtgtgagccacggtgcccagccCACTGTCTTTTTTCATCAATGCTAAGAGAATTTAATTCTTTCCACATGAAGCGATTCTACTTCC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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