Basic Information
VIS ID
TVIS44023651
Fusion event
HTLV-1-TMEM63C integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q24.3
Reference genome
GRCh37/hg19
Start
77706106/77239763 (Hg38)
End
77706106/77239763 (Hg38)
Orient
-
Location type
Intronic
Target gene
TMEM63C
miRNAs that regulate target gene
hsa-mir-4739 ; hsa-mir-6780a-5p ; hsa-mir-6779-5p ; hsa-mir-3689c ; hsa-mir-3689b-3p ; hsa-mir-3689a-3p ; hsa-mir-30b-3p ; hsa-mir-1273h-5p ; hsa-mir-185-3p ; hsa-mir-762 ; hsa-mir-5001-5p ; hsa-mir-4498 ; hsa-mir-6781-5p ; hsa-mir-4492 ; hsa-mir-6877-5p ; hsa-mir-6799-5p ; hsa-mir-6883-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-7106-5p ; hsa-mir-5787 ; hsa-mir-765 ; hsa-mir-4505 ; hsa-mir-6081 ; hsa-mir-3192-5p ; hsa-mir-4508 ; hsa-mir-6784-5p ; hsa-mir-1225-3p ; hsa-mir-1233-3p ; hsa-mir-1236-5p ; hsa-mir-1245a ; hsa-mir-125a-5p ; hsa-mir-125b-5p ; hsa-mir-4319 ; hsa-mir-4765 ; hsa-mir-579-3p ; hsa-mir-664b-3p ; hsa-mir-6779-3p ; hsa-mir-7976 ; hsa-mir-8079
Nearest miRNA
hsa-mir-208a/Upstream/2759559; hsa-mir-1185-1/Downstream/26455;
Nearest TSS
ENST00000550708/Upstream/57936; ENST00000557504/Downstream/11946;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/57778, chr14-CpG: 116/Downstream/30627
Upstream sequence
ATGATCAGGATCCACCCCTGTGCCCGCCTGTGCTTCTGCAAGTGCTGGACCTGCTTCAAGGAGGTAACTGGCTTGAGCGTTGGGAGCACAGCAAGGGAGC
Downstream sequence
GGTGGGGTCCTGGGGCTCTAGGCTCTGTGCCTTTGCCCGCACTGTTGGGCCCCAGGCCTCACTCAGGTCTGCTCTAGTGCTCCCCACCCAGCTCCTTCCT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
Curate