Basic Information
VIS ID
TVIS44023653
Fusion event
HTLV-1-ADCK1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q24.3
Reference genome
GRCh37/hg19
Start
78310891/77844548 (Hg38)
End
78310891/77844548 (Hg38)
Orient
+
Location type
Intronic
Target gene
ADCK1
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-mir-1260a/Upstream/578258; hsa-mir-1185-1/Downstream/16103678;
Nearest TSS
ENST00000550708/Upstream/44409; ENST00000555333/Downstream/57837;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/44156, chr14-CpG: 37/Downstream/121494
Upstream sequence
GTGCTCAATGCAAAGGAACCGGTGTCCCTTCATCCTATCATGTCAGTGGCGTTGGTCTTAGCTCTCCCCCCTGTTGGACTCCCTTAGAGAGGCAGTGTGG
Downstream sequence
GGAGCCGGCCCCGTCAGGTCCACCAAGAGCAGACTCGGTCTGTGTAACTCAGATTGGGCGTTGGCCTGGAGTGTAGTTCATTGGGACAGGGGAGAAAATG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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