Basic Information
VIS ID
TVIS44023674
Fusion event
HTLV-1-ATG2B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q32.2
Reference genome
GRCh37/hg19
Start
96787502/96321165 (Hg38)
End
96787502/96321165 (Hg38)
Orient
+
Location type
Intronic
Target gene
ATG2B
miRNAs that regulate target gene
hsa-mir-130a-3p ; hsa-mir-421 ; hsa-mir-30d-5p ; hsa-mir-20a-5p ; hsa-mir-106b-5p ; hsa-mir-3692-3p ; hsa-mir-7159-5p ; hsa-mir-505-3p ; hsa-mir-4709-5p ; hsa-mir-4272 ; hsa-mir-154-5p ; hsa-mir-10a-3p ; hsa-mir-19b-3p ; hsa-mir-19a-3p ; hsa-mir-181d-5p ; hsa-mir-181b-5p ; hsa-mir-181c-5p ; hsa-mir-181a-5p ; hsa-mir-519d-3p ; hsa-mir-93-5p ; hsa-mir-17-5p ; hsa-mir-20b-5p ; hsa-mir-1303
Nearest miRNA
hsa-mir-1260a/Upstream/1183179; hsa-mir-1185-1/Downstream/3788254;
Nearest TSS
ENST00000550708/Upstream/9902; ENST00000555088/Downstream/1270;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/281100, chr14-CpG: 101/Downstream/41964
Upstream sequence
tgttctctgaatctcattttcaagaccactgAAGTAATGTGAACCCTAGAAGAATCCTGGAACTTAATTTTCTGATTCTAAGAGCAAAAGTCAATAGCAC
Downstream sequence
CCAGTGAGAAAACCCAGGGTTTATTACTAACATTTAAGGAATAAATACCGAGTGGTATCTGATACCAAGTAAACCTACAGCAGAAACAACAGTCTGAAGT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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