Basic Information
VIS ID
TVIS44023676
Fusion event
HTLV-1-PCSK6 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr15
Cytoband
q26.3
Reference genome
GRCh37/hg19
Start
101862384/101322179 (Hg38)
End
101862384/101322179 (Hg38)
Orient
+
Location type
Intronic
Target gene
PCSK6
miRNAs that regulate target gene
hsa-mir-454-3p ; hsa-mir-6842-3p ; hsa-mir-647 ; hsa-mir-3187-3p ; hsa-mir-4435 ; hsa-mir-588 ; hsa-mir-4701-5p ; hsa-mir-548s ; hsa-mir-1273e ; hsa-mir-5787 ; hsa-mir-4505 ; hsa-mir-4430 ; hsa-mir-3652 ; hsa-mir-4529-5p ; hsa-mir-219b-3p ; hsa-mir-3190-5p ; hsa-mir-6782-3p ; hsa-mir-302f
Nearest miRNA
hsa-mir-10393/Upstream/2537677; hsa-mir-1302-10/Downstream/638280;
Nearest TSS
ENST00000557528/Upstream/5790; ENST00000558696/Downstream/12075;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/26438, chr15-CpG: 23/Downstream/76261
Upstream sequence
GAACGTAAAGAGCACCCTCAGGAAGCCGTGAAGATGTCAGGAGCTGGGAGAAAAAGAGAAGACCGAGGGATGCAGAGGAGAGAGGGTGGGTGAGCCGCTA
Downstream sequence
CAGCCCATCCCCGGCCCAGACAGCGAGGGGAACTGGAGCAGGTGGAGGTGCTGGAGCGAAAGGAGGCGGATCTGGGCACAGCCCTGTGCTGTACGTGATG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
Curate