Basic Information
VIS ID
TVIS44023681
Fusion event
HTLV-1-OCA2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr15
Cytoband
q13.1
Reference genome
GRCh37/hg19
Start
28093010/27847864 (Hg38)
End
28093010/27847864 (Hg38)
Orient
-
Location type
Intronic
Target gene
OCA2
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-181a-5p ; hsa-mir-6515-5p ; hsa-mir-6869-5p ; hsa-mir-5706 ; hsa-mir-526b-5p ; hsa-mir-4782-5p ; hsa-mir-516b-5p ; hsa-mir-1299 ; hsa-mir-6797-5p ; hsa-mir-1249-5p ; hsa-mir-6783-5p
Nearest miRNA
hsa-mir-1268a/Upstream/1999039; hsa-mir-10393/Downstream/578627;
Nearest TSS
ENST00000557528/Upstream/72243; ENST00000565126/Downstream/251429;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/41220, chr15-CpG: 39/Downstream/54915
Upstream sequence
CCATTTCTGTTACATTAACTGAGGTATTTGTGATAGTAGGGAAAGGAAGATGCAAAACCAGCCGGTGTTAGCCGTAGGAAGCATTTACCTCCTGGGGACA
Downstream sequence
GGCAGTCCCAGGTGGCACAAGTCCAGACACAGCGACAGCAGAGCTCTGTGGCGCCGTCAGGACCTGCTCCCTGCACCTGTGCGCTCTGCCACCTGCCAGC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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