Basic Information
VIS ID
TVIS44023687
Fusion event
HTLV-1-MEIS2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr15
Cytoband
q14
Reference genome
GRCh37/hg19
Start
37293718/37001517 (Hg38)
End
37293718/37001517 (Hg38)
Orient
-
Location type
Intronic
Target gene
MEIS2
miRNAs that regulate target gene
hsa-mir-204-5p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-218-5p
Nearest miRNA
hsa-mir-1233-1/Upstream/28616; hsa-mir-10393/Downstream/4690068;
Nearest TSS
ENST00000557528/Upstream/97450; ENST00000559509/Downstream/92512;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/112805, chr15-CpG: 27/Downstream/96457
Upstream sequence
CTGGACTCTCATTTTCTCATAAACCTACTCCTGTTTTATTTATTTGAATAGTTACTGGCATTCTAATATAGTCAGGCCCAAAACCCTAGCAGTATGTTGG
Downstream sequence
ATTGCTTCCCCCTCTTTCCCTGTTCACCACACTTAGATTGCCAGAATATGCAGATTCTTCCTCCAGACTATTTCTCATACTTATCTCCTCACTTCCATTT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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