Basic Information
VIS ID
TVIS44023691
Fusion event
HTLV-1-VPS18 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr15
Cytoband
q15.1
Reference genome
GRCh37/hg19
Start
41187053/40894855 (Hg38)
End
41187053/40894855 (Hg38)
Orient
+
Location type
Exonic
Target gene
VPS18
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-615-3p ; hsa-mir-324-3p ; hsa-mir-665 ; hsa-mir-3159 ; hsa-mir-6873-3p ; hsa-mir-516a-5p ; hsa-mir-6817-3p ; hsa-mir-3907 ; hsa-mir-7110-3p ; hsa-mir-3615 ; hsa-mir-4735-3p ; hsa-mir-18b-5p ; hsa-mir-18a-5p ; hsa-mir-6730-5p ; hsa-mir-7854-3p ; hsa-mir-6816-5p ; hsa-mir-3196 ; hsa-mir-3180-3p ; hsa-mir-3180 ; hsa-mir-6787-5p ; hsa-mir-663a ; hsa-mir-1908-5p ; hsa-mir-744-5p ; hsa-mir-1307-3p ; hsa-mir-361-3p ; hsa-mir-6764-5p ; hsa-mir-1915-3p ; hsa-mir-6837-5p ; hsa-mir-4685-5p ; hsa-mir-3918 ; hsa-mir-25-5p ; hsa-mir-362-5p ; hsa-mir-455-3p ; hsa-mir-500a-5p ; hsa-mir-500b-5p ; hsa-mir-508-3p ; hsa-mir-6125 ; hsa-mir-6499-3p ; hsa-mir-6516-5p ; hsa-mir-658 ; hsa-mir-6807-5p ; hsa-mir-377-5p ; hsa-mir-6086
Nearest miRNA
hsa-mir-1233-1/Upstream/3921954; hsa-mir-10393/Downstream/796730;
Nearest TSS
ENST00000557528/Upstream/388; ENST00000503052/Downstream/11956;
Nearest CpG islands
chr15-CpG: 21/Target, None/Upstream, None/Downstream
Upstream sequence
GAGGCCGGGCACCATGGCGTCCATCCTGGATGAGTACGAGAACTCGCTGTCCCGCTCGGCCGTCTTGCAGCCCGGCTGCCCTAGCGTGGGCATCCCCCAC
Downstream sequence
TCGGGTAAGGAAGAGGAGGGTGCCGCTGCCCCTTTCGGCTCTCCTAGCATTTGCGTGGGAGCAGCGAGGAGGGCAGCTCCAAGAGCTCGGGGTCATCCCC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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