Basic Information
VIS ID
TVIS44023698
Fusion event
HTLV-1-TMOD2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr15
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
52100854/51808657 (Hg38)
End
52100854/51808657 (Hg38)
Orient
-
Location type
UTR3
Target gene
TMOD2
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-34a-5p ; hsa-mir-484 ; hsa-mir-4443 ; hsa-mir-7847-3p ; hsa-mir-3612 ; hsa-mir-650 ; hsa-mir-6862-3p ; hsa-mir-6784-3p ; hsa-mir-6847-5p ; hsa-mir-4257 ; hsa-mir-500b-3p ; hsa-mir-3680-5p ; hsa-mir-4798-3p ; hsa-mir-578 ; hsa-mir-3679-3p ; hsa-mir-526b-5p ; hsa-mir-1236-3p ; hsa-mir-519d-5p ; hsa-mir-199b-5p ; hsa-mir-199a-5p ; hsa-mir-1825 ; hsa-mir-3145-5p ; hsa-mir-3941 ; hsa-mir-4789-3p ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485 ; hsa-mir-5692a ; hsa-mir-640 ; hsa-mir-6754-3p ; hsa-mir-412-3p ; hsa-mir-1224-3p ; hsa-mir-3934-5p ; hsa-mir-764 ; hsa-mir-125a-3p ; hsa-mir-1306-5p ; hsa-mir-6821-3p ; hsa-mir-6790-3p ; hsa-mir-150-5p ; hsa-mir-186-3p ; hsa-mir-378a-5p ; hsa-mir-203b-3p ; hsa-mir-7158-3p ; hsa-mir-4680-5p ; hsa-mir-3653-5p ; hsa-mir-4635 ; hsa-mir-4716-5p
Nearest miRNA
hsa-mir-10393/Upstream/494548; hsa-mir-11181/Downstream/468460;
Nearest TSS
ENST00000557528/Upstream/25835; ENST00000558455/Downstream/20971;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/56407, chr15-CpG: 82/Downstream/20962
Upstream sequence
CGTTAACCACATAACTAATAATTTAATTGTTATTCTTTTTTAGCACTACTTATTTATCTTGGATTTTGTAATATATGCAATTGTTTTATTTGCTCATGGG
Downstream sequence
CACTTCTGGCAACTTGACAAATGGACCGATGCAGATTTTAGAGAGTGACGACATGGAAAATGAATTTAACCACTTTCTTATTGGGTTGTCTTGCTTTCTT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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