Basic Information
VIS ID
TVIS44023705
Fusion event
HTLV-1-UNC13C integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr15
Cytoband
q21.3
Reference genome
GRCh37/hg19
Start
54824667/54532469 (Hg38)
End
54824667/54532469 (Hg38)
Orient
+
Location type
Intronic
Target gene
UNC13C
miRNAs that regulate target gene
hsa-mir-128-3p
Nearest miRNA
hsa-mir-10393/Upstream/2255269; hsa-mir-11181/Downstream/840471;
Nearest TSS
ENST00000557528/Upstream/31498; ENST00000560537/Downstream/76873;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/772662, chr15-CpG: 52/Downstream/664075
Upstream sequence
catgcatgcatatgctcattgcaacactattcacaatagcaaagtaaggcatcaacctaaatgcccatcaaccctagactggataaagaaactatggtac
Downstream sequence
atatacaccatgaaatactattcagccaaaaaaaggaacaacatcatgtcctttgcagggacatggatggagttggaggccgttatcattagcaaactaa
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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