Basic Information
VIS ID
TVIS44023708
Fusion event
HTLV-1-ADAM10 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr15
Cytoband
q21.3
Reference genome
GRCh37/hg19
Start
59025523/58733324 (Hg38)
End
59025523/58733324 (Hg38)
Orient
-
Location type
Intronic
Target gene
ADAM10
miRNAs that regulate target gene
hsa-mir-122-5p ; hsa-mir-155-5p ; hsa-mir-484 ; hsa-mir-32-5p ; hsa-mir-92b-3p ; hsa-mir-92a-3p ; hsa-mir-451a ; hsa-mir-103a-3p ; hsa-mir-448 ; hsa-mir-655-3p ; hsa-mir-449a
Nearest miRNA
hsa-mir-10393/Upstream/3360290; hsa-mir-11181/Downstream/437859;
Nearest TSS
ENST00000557528/Upstream/54042; ENST00000559745/Downstream/15642;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/666746, chr15-CpG: 125/Downstream/15558
Upstream sequence
GCTGTCAGCCAGAAGTTGAACTGCTCCATCTATCCACAATGTAGAGATTACCTACAACTAGGTGAGTGAACAAAACCTGGTGGTTCTTCATCCCCTCCCT
Downstream sequence
CAGAGTGGTTTCAGTGTGGAAATGACCCAGCTCCTGCCCAAAAGACCTGGGTTGGGGTCTGCTGTGGATTTCCAGAGGTCCCCCTTTTTTGTGGACAATG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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