Basic Information
VIS ID
TVIS44023720
Fusion event
HTLV-1-ANP32A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr15
Cytoband
q23
Reference genome
GRCh37/hg19
Start
69109786/68817447 (Hg38)
End
69109786/68817447 (Hg38)
Orient
+
Location type
Intronic
Target gene
ANP32A
miRNAs that regulate target gene
hsa-mir-21-5p ; hsa-mir-1-3p ; hsa-mir-148a-3p ; hsa-mir-940 ; hsa-mir-877-5p ; hsa-mir-615-3p ; hsa-mir-320a ; hsa-mir-3163 ; hsa-mir-374a-3p ; hsa-mir-568 ; hsa-mir-203a-3p ; hsa-mir-6826-3p ; hsa-mir-1236-3p ; hsa-mir-6892-3p ; hsa-mir-6795-3p ; hsa-mir-6887-3p ; hsa-mir-361-3p ; hsa-mir-770-5p ; hsa-mir-4712-5p
Nearest miRNA
hsa-mir-10393/Upstream/15522; hsa-mir-11181/Downstream/1261925;
Nearest TSS
ENST00000557528/Upstream/25199; ENST00000561467/Downstream/152;
Nearest CpG islands
chr15-CpG: 355/Target, None/Upstream, None/Downstream
Nearest cancer related gene
ANP32A(TSG, No orient, 0)
Upstream sequence
GCTGCAACATCCACCTGAAACACGGAGCTCGACCTACCTTCCCGGAGAGCCCAGCCCGGGAGGGCGTTTCCCCAACGGATCGACAACTCTTCCCTCCCGG
Downstream sequence
GGAACAGGCTGCTGTCCTTGGCTTCAGTCAGGGCCACTAGAGTCGCGTGCGCGACACCCCTCACCCCCGCCAAAAGAACCTCATGTTTAATGTTCCCCTT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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