Basic Information
VIS ID
TVIS44023729
Fusion event
HTLV-1-LINGO1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr15
Cytoband
q24.3
Reference genome
GRCh37/hg19
Start
78105683/77813341 (Hg38)
End
78105683/77813341 (Hg38)
Orient
+
Location type
Intronic
Target gene
LINGO1
miRNAs that regulate target gene
hsa-mir-196a-3p ; hsa-mir-765 ; hsa-mir-766-5p ; hsa-mir-6077
Nearest miRNA
hsa-mir-10393/Upstream/2051026; hsa-mir-11181/Downstream/1396447;
Nearest TSS
ENST00000557528/Upstream/25269; ENST00000565869/Downstream/6111;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/178321, chr15-CpG: 206/Downstream/5158
Upstream sequence
ttaatgaggcatttgggctaagccttaaaaagtgggtgggatctccacggacagggatgggggagaactctcaggtggaaggaccatggaggaggacagc
Downstream sequence
gacagcccatctgattggctggagcctggggacacagagaggtgcttaggagagagggctggggtgggacataggCTTGGGCAAGGTGCCGAGGGGTCAG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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